Student guest post on drug repurposing

Antiques Become Modern

     The repositioning continued movement for drugs means discovering new clinical benefits in opposition to a drug that has been before that time approved to treat other diseases or stipulations, according to The National Center in spite of Advancing Translational Sciences, part of the National Institutes of Health (NIH), US Department of Health and Human Services. It has been estimated that 30% of of the present day drugs and vaccines approved by the US FDA in novel years attributes to the process of drug repurposing, repositioning, and rescue. This protuberance offers many advantages including the costs and time saved from circumventing the comprehensive testing typically required for demonstrating the safety of a newly developed drug. Since these drugs be seized of already been approved for human application, the well characterized properties (pharmacology, science of poisons, and formulation) of these candidates let for the process involved in therapeutic switching to a novel clinical application to occur relatively quickly. Because of the comprehensive financial commitments and time required ~ the sake of developing a new drug, the goal of bringing a unused drug to market with a with reference to something else low cost is very attractive.  The require to be paid associated with the development of a fresh drug is estimated at over $2 billion, and the timeline typically involves else than 12 – 16 years. In difference, a repurposed drug can be approved in ~y extensively shorter time frame, 3- 12 years, through an average cost of $300 the multitude. In addition, approval rates for just discovered drugs are typically close to 10%, only is often 30% for therapeutically switched drugs. Finally, the suit of repositioning of drugs could depict substantial assistance for low income patients who wish chronic diseases, for example autoimmune lymphoproliferative syndrome (ALPS), inasmuch as they can obtain their medications according to considerably lower prices.

     There are a figure of successful drug repurposing stories. Perhaps the greatest in quantity famous stories of a repurposed deaden with narcotics involves thalidomide. Thalidomide had been used to refreshment morning sickness in pregnant women in the 50s of the highest century, then it was withdrawn from markets debt to birth deformities. This drug has been synthesized during the time that racemic mixture because it is a chiral medley. Lately, it was discovered that common of the enantiomers (the (R)-(+)-enantiomer) was adequate to treat pregnant morning sickness, time, the (S)-(-)-enantiomer made the inborn malformations. Nowadays, this drug has been repurposed and has been approved through FDA to treat leprosy in 1998 and multiple myeloma in 2006. Another success story involves sildenafil. This drug was originally developed to discuss hypertension, but it failed during unravelling. However, during clinical trials, it was noticed that sildenafil could improve erectile dysfunction. As a termination, it was approved to treat erectile dysfunction. Since that time, sildenafil has been subjected on account of further re-tasking and is at this moment approved to treat pulmonary hypertension.

References:

1.      I. Agranat, H. Caner, J. Caldwell, “The Thalidomide Tragedy: The Myth of a Missed Opportunity,” Nature Reviews Drug Discovery 1, 753-768 (2002).

2.      https://ssir.org/articles/avenue/repurposing_social_impact_bonds_for_medicine.

3.      28. Joseph A. DiMasi & Henry G. Grabowski, The Cost of Biopharmaceutical R&D: Is Biotech Different?, 28 MANAGERIAL & DECISION ECON. 469, 469 & 475 (2007).

4.      UNITED STATES GOVERNMENT ACCOUNTABILITY OFFICE (GAO), NEW DRUG DEVELOPMENT: SCIENCE, BUSINESS, REGULATORY, AND INTELLECTUAL PROPERTY ISSUES CITED AS HAMPERING DRUG DEVELOPMENT EFFORTS 1 (2006).

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