ANTI EPILEPTIC DRUG (AED) THERAPY IN NEURO INTENSIVE CARE

▪️Mechanisms, that be able to contribute to the development of seizures later craniotomy: (1) Free radical generation, appropriate to iron and thrombin from kindred components that have leaked in the fabric during surgery. (2) Disturbance of ion equalizer across the cell membranes due to limited ischemia or hypoxia.

▪️Investigations that should be considered, in the result of an episode of postoperative seizures : Serum electrolytes, grape-sugar, AED concentrations, ammonia and liver enzymes, science of poisons screen, ABG, CT Brain & EEG (to restrain ongoing nonconvulsive seizures or SE). Derangements such as hypoglycemia, hyponatremia, hypocalcemia, hypomagnesemia, hypoxia or hyper-or hypocarbia should subsist corrected.

▪️ 5-20 Minutes Initial Therapy Phase^

A benzodiazepine is the initial therapy of choice (Level A): Can conversion to an act either among the three

▶️Intramuscular midazolam (10 mg on account of > 40 kg, 5 mg during 13-40 kg, single dose, Level A) OR ▶️Intravenous lorazepam (0.1 mg/kg/disagreeable lot, max: 4 mg/dose, may reproduce dose once, Level A) OR ▶️Intravenous diazepam (0.15-0.2 mg/kg/prescribed portion , max: 10 mg/dose, may quote dose once, Level A) 

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