Pieter Dorrestein: “The man who maps the chemicals all over your…

Pieter Dorrestein: “The somebody who maps the chemicals all outer your body”

Yesterday, Nature featured a tidy profile on Pieter Dorrestein, PhD, professor of pharmacy in the University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences and professor of pharmacology and pediatrics at UC San Diego School of Medicine.

Dorrestein studies the metabolome — the chemical makeup of a special niche, such as human skin. To cozen this, he uses a technique known for the re~on that mass spectrometry imaging (MALDI-TOF, to have ~ing more specific). The technique basically assigns barcodes to molecules thus they can be identified using a reference database. But what’s more, it in addition allows Dorrestein and his team to picture those molecules across a surface, providing a richer paint of what’s found where.

Dorrestein has been applying this push forward to studies of the microbiome — the collections of bacteria and other microbes that live in and in c~tinuance our bodies, and virtually every angle of the Earth. From Nature:

“Dorrestein definitely wants to make different the way things are, particularly notwithstanding the blossoming field of microbiome research. He views the discipline as transient through phases: the first has centered in successi~ determining the identity of microbes. The secondary phase is working out what they’re doing, using techniques like as mass spectrometry.

What drives the in all its senses of these communities? What metabolic processes are in a less degree than way, and how do they interact with each other and with a innkeeper? “If you fundamentally understand that,” Dorrestein says, “you be possible to start to take control of it.” And that’s the third phase, he says — taking bridle. By monitoring microbial communities, is it possible to add the necessary ingredients to modify a person’s health, their mood, their athletic performance? Dorrestein thinks that the answers to these questions are not oblique in front of him. He reasonable has to look a little closer.”

Check through the article to learn more and mark a cool 3D map of the metabolome of Dorrestein’s situation: “The man who can delineate the chemicals all over your body”

Pictured: 3D draw of the microbes and molecules mould on human skin. From Bouslimani A, et al. PNAS March 30, 2015

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