Compound from unique blue-green algae could be key to next anti-cancer drug

Could a slippery glob of algae hold the explanation to the next anti-cancer unsalable article? According to new research into a composite produced by a unique community of azure-green algae, the answer could have existence yes.

ChemSpider 2D Image | coibamide A | C65H110N10O16

The compound in question is called coibamide A, discovered eight years ago by scuba-diving scientist Kerry McPhail, Ph.D., of Oregon State University. A reinvigorated study shows coibamide A has mighty anti-cancer activity in mice and small room cultures that model brain tumors and make threefold negative breast cancer, two of the principally aggressive and difficult-to-treat types of cancer.

“The chemical difference found in nature has always been a expressive source of inspiration for drug design and progression in a continuously ascending gradation, but although the medicinal properties of plants hold been recognized for thousands of years, pelagic environments remain relatively unexplored,” said Jane Ishmael, Ph.D., fraternize professor of pharmacology at Oregon State University and the precede author of the new study. “We design that with this compound, nature has before that time found a way to target some of the specific proteins that are to the purpose to the growth of tumors.”

Ishmael choose present this research at the American Society on account of Pharmacology and Experimental Therapeutics Annual Meeting during Experimental Biology 2016.

McPhail, who specializes in dispiriting-green algae and dives all by the world in search of pleasing species, collected the algae during a plunge in Panama’s Coiba National Park. It turned exhausted to be a mash-up of at least three algal species that grow in concert on rocks in areas with wildly-moving water. In addition to Panama, resembling algal communities has been found in the Red Sea and right side the coast of South Africa. Blue-blooming algae, or cyanobacteria, have existed in favor of at least two billion years and are individual of the oldest life forms without interrupti~ Earth.

After McPhail isolated coibamide A from the original algal specimen, it was run end a National Cancer Institute screening universe that looks for potential anti-cancer spryness across 60 different types of cancer. Coibamide A showed a follow of activity unmatched by any other medley, suggesting it might be able to draw the sword cancer through a mechanism of enacting unlike that of any existing unsalable article.

Compound from unique blue-green algae could have ~ing key to next anti-cancer drug: Could a slippery glob of algae clinch the key to the next anti-cancer mix with ~s? According to new research into a hodge-podge produced by a unique community of down in the mouth-green algae, the answer could subsist yes.

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