Biological products: alternative, substitute or supplement for allergen immunotherapy

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What are they?

Biologics, besides called biological response modifiers, are biological molecules and, usually, they are proteins. They come from somewhat of the biological compounds that they have power to act on. Their role lies in in what way they can target specific components of the immune arrangement that contribute to the disease under which circumstances preserving intact necessary immune functions. These biological modulators include monoclonal antibodies, cytokine inhibitors, blockers of receptors and making homogeneous.

There are different types of biologics: 1) uniform to the immune system, but mutated with some small change in its composition so that it can block the receptors that own the original molecule and correct a complaint. This is what we refer to in the manner that mutagens. 2) On other occasions biologics are antibodies that ~ up, inactivate or eliminate the natural biological atom that is causing the disease or infuriate symptoms. They are called monoclonal antibodies. 3) Finally, biologics are too being manufactured as products containing single or more active regions of real molecules to enhance their action or spur a response that the body is not proficient to generate. They are what I resolution name mimetic molecules and that be possible to be used in vaccines or immunotherapy.

Biologics are some authentic revolution in modern pharmacology because they are showing very good curative results in complex diseases where numerous factors are involved and for which there are no chemical drugs. Today, regulatory agencies go over again and approve numerous molecules of this accommodating every year and their number is increasing. The most recent of these has been ~y anti-Il-5 for the management of asthma (mepolizumab) approved at the cessation of 2015 by the FDA and EMA, end there are a lot more without interrupti~ their way.

Can they be used as far as concerns the treatment of allergies?

The expanding of biologics began to treat diseases in the same manner with rheumatoid arthritis or lupus for prototype, but in recent years there has been ~y exponential growth in research of this symbol of molecules for the treatment of asthma and respiratory diseases, and therefore of diseases related with allergy.

In this regard, the primitive biological developed exclusively for diseases allied to allergy was omalizumab, a recombinant and humanized IgG1 monoclonal antibody by ability to reduce IgE levels and what one. use for the treatment of asthma in patients allergic is giving worthy of great praise results. Recently its use has begun to be unfolded to the problems associated with atopy and is publicly under investigation for food allergies. Studies through other products of this kind, similar as the mepolizumab are ongoing by promising results.

Substitutives or enhancers?

It really is too early to answer it today, unless certainly these treatments are here to stay and are helping to behave toward patients with severe uncontrolled asthma. On the other guide, works with these products in rations allergy have already started and with a clear objective of promoting modifying agent immunological pathways.

The alternative of the combinations of biologics (with ability to reduce symptoms and precise the pathological routes), along with the application of conventional immunotherapy, which is answerable for inducing tolerance to allergens, is one option that today sounds very entertaining but has not been worked in measure. Some promising studies have started if it were not that there is a lack of philosophical basis and their usefulness has to exist proved. The option is open. What we send for today mimetic molecules encompass the known recombinant allergens. The guide may lay in their ability to provoke the immune response of tolerance.

And from the preservation point of view?

The main point in dispute with biologics lies in the immunogenicity and allergenicity. The dead ~ itself can make antibodies against biologics, with equal rea~n that they are rendered useless one time administered. There have also been described allergic reactions to them, forcing the discontinuation of their application.

And in summary?

In short we be possible to say that biologics already play some important role in the treatment of allergic malady, mitigating the effects and substantially improving the property of life of patients. New products and applications are subsistence studied. But the great challenge that lies forward is to actually cure or actuate the required tolerance to allergens. If in that place will be only the biologics or their compound with allergenic extracts is to subsist seen. Certainly should keep an inspection on this.

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