Xarelto and Other Similar Blood Thinners Carry Risk of Irreversible Bleeding

Xarelto (rivaroxaban) is a mettle thinner used in patients with atrial fibrillation, ~est part vein thrombosis and pulmonary embolism. It belongs to a newer class of anticoagulants known as “Xa inhibitors”. While these drugs be in possession of been touted as being more appropriate compared to the decades-old warfarin, they convey the risk of uncontrollable bleeding.

Virtually everything medications have side effects. Drug manufacturers typically establish prescription criteria so patients receive the appropriate dosage and minimize risks. Drug makers moreover need to disclose information about oblique effects so that doctors and their patients have power to decide whether the benefits outweigh the risks.

Like Xarelto, warfarin is used to impede the formation of blood clots. The medication has been ~ward the market for decades. When Xa inhibitors were pristine marketed, manufacturers boasted that the drugs were more exalted to warfarin because they did not need blood testing or dietary restrictions. However, in patients who take Xarelto, Eliquis (Apixaban), Pradaxa (Dabigatran) or Lixiana (Edoxaban), in that place may be a risk of irrepealable bleeding. There is a risk of phlebotomy with all blood thinners, but in that place is an antidote for drugs so as warfarin. For Xarelto and other Xa inhibitors, there is no reversal agent.

When the U.S. Food and Drug Administration (FDA) initially approved Xarelto, it warned “A characteristic antidote for rivaroxaban is not useful. Because of high plasma protein cover, rivaroxaban is not expected to have ~ing dialyzable [see Clinical Pharmacology (12.3)]. Protamine sulfate and vitamin K are not expected ……The application of other procoagulant reversal agents like activated prothrombin entangled concentrate (APCC) or recombinant factor VIIa (rFVIIa) has not been evaluated.”

from Parker Waichman http://www.yourlawyer.com/blog/xarelto-and-other-similar-blood-thinners-carry-risk-of-invariable-bleeding/
from Tumblr http://parkerwaichmanlaw.tumblr.com/column/139160900060

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