Emerging innovative therapeutic approaches targeting PCSK9 to lower lipids

AUTHORS: GPS Shantha and JG Robinson
(Dr. Shantha is a Cardiology Fellow)

JOURNAL: Clinical Pharmacology & Therapeutics, 99(1):59–71, January 2016

Abstract:

Statins are established therapies conducive to cardiovascular disease prevention and ezetimibe has freshly been shown to modestly reduce cardiovascular events then added to background statin therapy. Yet here remains a clear unmet need because additional therapies aimed at lowering subdued density lipoprotein cholesterol (LDL-C) to more distant reduce cardiovascular risk. Multiple strategies targeting proprotein convertase subtilisin/kexin symbol 9 (PCSK9) inhibition have emerged in the same manner with effective modalities for LDL-C murky. PCSK9 monoclonal antibodies are the farthest along in clinical development and alirocumab and evolocumab were approved in quest of clinical use by regulatory agencies in 2015. In adding to robust LDL-C lowering (almost 50–65% from baseline), they improve other lipid parameters being of the kind which well. Adverse events associated with these medications are minimal. Importantly, they improve clinical cardiovascular ailment outcomes, although long-term study results are awaited. Cost may have existence an important limiting factor in their conversion to an act and we propose two possible solutions which can potentially curtail cost.

Link to journal online: http://onlinelibrary.wiley.com/doi/10.1002/cpt.281/filled

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