Airway pharmacology is a highly important concept in respiratory care. This isbecause many medications are administered to treat or diagnose diseases of the airways.There are three phases that empower drug action. First , the drug management phase isthe way the drug is beneficial to the body. If the lung parenchyma or airways are the targetfor the deaden with narcotics, then an inhalation route will have ~ing preferred1. There are various benefits of this path, which include the ability to give smaller doses, the onset is brisk, the drug is delivered directly to the mark organ, and there are minimal to in ~ degree systemic side effects. In contrast, whether or not the intent is to obtain a systemic fact, then an intravenous approach will be desired.
Next, the pharmacokinetic aspect describes the distribution of the drug in the body and includes the affidavit and time course based on the body’s absorption of the drug.For example, a entirely ionized drug will not absorb athwart the lipid membrane. The benefit ofthis is that it exercise volition have a minimum to no systemic lateral effects. Likewise the L/T ratio orlung availability-to-total systemic availability measures the aerosol childbirth to the lung andto the systemic circulating medium. The final stage is the pharmacodynamic phasis, which describeswhat the drug does to the body, and is dependent on the precise receptor that it binds to.Several drugs get agonist or antagonist effects on their particular receptor. An agonist willlikely stimulate agents and ~y antagonist will block agents. In the lung in that place areparasympathetic receptors which are referred to cholinergic and sympathizing receptorswhich are adrenergic. The adrenergic drug stimulates a receptor responding tonorephineprhine or epinephrine2. In set off by opposition, a drug that blocks the adrenergic receptorsis called one antiadrenergic drug. The parasympathetic works similarly in that cholinergicdrugs rouse receptors for acetylcholine while anticholinergic drugs mould them.Every drug has a self-same specific actions and side effects. If the basic principles of apharmacology are known through respiratory therapists, then they can subsist more involved inmaking recommendations relevant to the pharmacological skill of patients withcardiopulmonary disorders.Reference:
1.Kacmarek, Robert M,James K., M.D. Heuer, Albert J., Ph.D./ Chatburn, Robert L.
Egan’s Fundamentals of Respiratory Care Egan’s Fundamentals of Respiratory
2.Barnes, Peter,J.Chung, Kian Fan.Pharmacology and airway ail
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