INDICATIONS: 1. Diuretic (particularly in the port of metabolic alkalosis) 2. Correction of sarcastic metabolic alkalosis
Diamox 250mg tablets
DOSAGE: For diuresis, the drench is usually 250-375 mg stat. If, posterior an initial answer, the patient fails to perpetuate to diurese, act not increase the drench but allow during the term of kidney recovery by skipping medication for a day. Acetazolamide yields superlatively good diuretic results at the time that given on alternate days, or during the term of 2 days alternating by a day of rest.
DOSAGE IN PAEDIATRICS: The preservation and effectiveness of acetazolamide in paediatric patients in the regions of the dead the age of 12 years be favored with not been established.
DOSAGE IN RENAL FAILURE AND RENAL REPLACEMENT THERAPY: No drench adjustment is required then administered for ICU indications (mind that acetazolamide is contraindicated in the presence of metabolic acidosis). This physic is not indicated in patients without ceasing renal replacement therapy.
CLINICAL PHARMACOLOGY Acetazolamide is one enzyme inhibitor that acts steady carbonic anhydrase, the enzyme that catalyzes the reversible reciprocal action involving the hydration of carbon sub-oxide and the dehydration of carbonic sour.
CONTRAINDICATIONS 1. Hypersensitivity to acetazolamide or other sulphonamides 2. Metabolic acidosis 3. Cirrhosis (venture of development of hepatic encephalopathy)
General Increasing the draught does not enlarge the diuresis and may augment the incidence of drowsiness and/or paraesthesia. Increasing the disagreeable lot often results in a lower in diuresis.
Acetazolamide and sodium bicarbonate used concurrently increases the peril of renal calculus disposition.
METABOLIC SIDE EFFECTS
Metabolic acidosis, electrolyte imbalance, including hypokalaemia, hyponatraemia, loss of appetite, taste mutation, hyper/hypoglycaemia.
Continued use for several weeks can already cause compassionate addiction, considerably more therefore if this devotion is pursued to greater amounts.