New article on hormones interacting with neurotransmitter receptors in PLOS ONE

ReseT3 interactions with GABA(A) receptorcunning from our collaboration with Dr. Joe Martin’s arrange here at Rutgers-Camden is things being so published in PLOS ONE: “Interactions of  L-3,5,4′-triiodothyronine, Allopregnanolone, and Ivermectin with the GABA(A) receptor: Evidence beneficial to Overlapping Intersubunit Binding Modes” by T. Westergard, R. Salari, J. V. Martin, and G. Brannigan.

In this bank-notes, we use experimental and computational methods to dissect the likelihood that thyroid hormone T3 and the neurosteroid allopregnanolone harden to intersubunit binding site(s) in the transmembrane sway of the GABA(A) receptor.  We likewise use results from Molecular Dynamics Simulation to propose one explanation for why mutagenesis studies are so frequently inconclusive for GABA(A) pharmacology.

Vicodin and produces massive part an identical affects as oxycodone.

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