A New “Squeak” on who is an Excellent Woman!

I often bond to the female of some species, even though all my dogs and three of my cats were masculine.  I love my boys, real, but, well, girls rock.  I but also feel sorry smacking mosquitoes and shooing spiders, for often, those that bite and figure web are female.  All knowledge of principles, nuisance, fear, and pain, aside, it doesn’t look fair, somehow, to swat one’s own kind.

Same with mice.  They  and I carry on not get along!   Well, I take for granted they are close to a hedgehog. But, beware this article below from the NY Times!

The New York Times

International New York Times






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Why Science Needs Female Mice


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July 18, 2015

Scientific scrutiny has a gender gap, and not condign among humans. In many disciplines, the animals used to study diseases and drugs are overwhelmingly male animal, which may significantly reduce the reliableness of research and lead to drugs that won’t act in half the population.

A starting a~ study published in the journal Nature Neuroscience suggests that inquiry done on male animals may not grasp up for women. Its authors reported that hypersensitivity to aggrieve works differently in male and female mice. For males, immune cells called microglia occur to be required for pain hypersensitivity, and inhibiting their part also relieves the pain. But in offspring-bearing mice, different cells are involved, and targeting the microglia has no effect. If these differences occur in mice, they may occur in humans over. This means a pain drug targeting microglia main appear to work in male mice, yet wouldn’t work on women.

Failure to consider gender in research is very plenteous the norm. According to one parsing of scientific studies that were published in 2009, male animals outnumbered females 5.5 to 1 in neuroscience, 5 to 1 in pharmacology, and 3.7 to 1 in physiology. Only 45 percent of animal studies involving debasement or anxiety and only 38 percent involving strokes used women, even though these conditions are further common in women.

In 1994, the National Institutes of Health confronted sex imbalance in clinical drug trials and began requiring that women and minorities exist included in clinical studies; women now make up around half of clinical effort participants. In June, the N.I.H. announced that it would institute requiring researchers to take gender into worth in preclinical research on animals considered in the state of well.

A lab mouse.

Zach Wise on account of The New York Times

Under the unused requirements, researchers applying for N.I.H. grants in January 2016 and later be pleased need to show “strong justification” allowing that they plan to study only the same sex. Justifications can include study of sex-limited conditions like ovarian cancer or limited availability of subjects of the couple sexes (as with primates).

This of the present day policy for grants sends a pretty large message to scientists and drug makers forward the importance of considering sex in subtle research projects, if they want to be apprised diseases that appear to affect men and women differently and advance in successive medicines effective for those diseases.

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