Pharmacology of 4-FA

4-FA (4-Fluoroamphetamine) aswell accepted in the same manner with para-fluoroamphetamine is a analysis actinic and substituted-amphetamine of the phenethylamine class. It produces both analeptic and entactogenic furnishings that are rather commensurable to MDMA.

4-fluoroamphetamine is a clearance abettor and reuptake inhibitor of dopamine, serotonin, and norepinephrine. The corresponding EC50 ethics are 2.0 x 10−7 M, 7.3 x 10−7 M, and 3.7 x 10−8 M, season the IC50 ethics are 7.7 x 10−7 M, 6.8 x 10−6 M, and 4.2 x 10−7 M.

Regarding the metabolic destruction of 4-FA, it is welcome excreted from the physique absolutely unchanged. The C-F band at the 4-state on the phenyl ring acceptable resists deactivation in the alarmist ~ the agency of cytochrome P450 oxidase.

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