Discovery may guide to new treatment options for arterial illness caused by obesity
COLUMBIA, Mo. (May 5, 2015) — A late study led by a University of Missouri researcher has identified the enzyme liable for obesity-related hypertension ― a finding that could lead to new usage options.
William Durante, a professor of medical pharmacology and physiology at the MU School of Medicine and persuade author of the study, said, “By comparing genetically fat rats to lean rats, we discovered that plump animals were deficient in the amino acid arginine due to elevated activity of the enzyme arginase, that breaks down this molecule.”
Although arginase is not absent throughout the body, it is primarily found in the liver. Its role is to take part with in the breakdown of ammonia, which is eventually flushed out during urination. However, Durante’s team found significantly increased arginase briskness within blood vessels and in the hot spark of obese rats compared to lay animals.
“The problem by this development is that arginase depletes arteries and consanguinity of arginine, which is needed to propagate nitric oxide,” Durante said. “Nitric oxide is a elastic fluid formed from arginine that relaxes descendants vessels and lowers arterial blood grievance. The destruction of arginine by arginase reduces nitric oxide levels, most important to the constriction of blood vessels and oppressive blood pressure.”
Using sum of ~ units methods to correct the arginine insufficiency, Durante’s team first supplemented the diet of plump animals with the amino acid L-arginine. The take part with method involved using drugs that block the activity of arginase. Although the two approaches restored nitric oxide production and reversed hypertension in stout rats, the use of arginase-inhibiting drugs may have existence a better solution.
“Blocking arginase briskness offers a more specific approach in treating hypertension, because you are directly targeting the underlying biochemical abandon allegiance in obesity,” Durante said. “L-arginine is a essential amino acid commonly found in red flesh , poultry, fish and dairy products. It is likewise manufactured and used as a nutritional postscript or medication. However, a dietary come near using L-arginine may not have ~ing the best treatment option. Yes, arginine increases nitric oxide, further it also exerts other biological furniture, and it can be converted ~ the agency of arginase to alternative compounds that neutralize its benefits to the circulation.”
In future studies, researchers plan to investigate the sort of causes the increase in arginase nimbleness in blood vessels and in the kindred of obese animals. However, Durante feels that identifying the role of arginase in the increase of obesity-related hypertension will finally benefit obese patients.
“Obesity is a indicative health issue not only in this inhabitants, but worldwide,” Durante said. “The guide to reversing the effects of plumpness-related hypertension will be to effectively stop up arginase activity. This new knowledge may support in the discovery of treatment options ~ the sake of obese patients with high blood crushing.”
The study, “Arginase Promotes Endothelial Dysfunction and Hypertension in Obese Rats,” was newly published in Obesity, the official diary of The Obesity Society. Funding beneficial to the study was provided by the National Institutes of Health and the American Heart Association.
About MU School of Medicine
The MU School of Medicine has improved hale condition, education and research in Missouri and remote from for more than 165 years. MU physicians delight patients from every county in the condition, and more Missouri physicians received their healing degrees from MU than from ~ one other university. For more information, examine http://medicine.missouri.edu/.
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