2C-E inhibits the reuptake of monoamines, that cover dopamine, norepinephrine, and serotonin – otherwise than that exerts its absolute activity aloft serotonin and norepinephrine. In apologue to added associates of the ‘2C’ series, Nagai et. al. empiric that 2C-E is a added the omnipotent. inhibitor of serotonin reuptake than 2C-I, yet beneath almighty than 2C-C. It is below almighty than both 2C-I and 2C-C at inhibiting the reuptake of norepinephrine, but. In allegory to added phenethylamines, 2C-E is appreciably under almighty at inhibiting both serotonin and norepinephrine reuptake than MDMA, Methylone, BDB, and MBDB. It appears to have existence added almighty than both TMA, TMA-2, and TMA-6 at inhibiting reuptake of one as well as the other serotonin and norepinephrine.
Additionally, 2C-E is a scarcely beneath almighty reuptake inhibitor for serotonin, and in fact a bit beneath almighty at inhibiting reuptake of norepinephrine, than BZP – similar to able-bodied as beneath almighty at inhibiting the reuptake of norepinephrine and serotonin than AMT, 5-MeO-MIPT, 5-MeO-DIPT, and 5-MeO-DMT.
When evaluated because its accommodation in breeding monoamine free, 2C-E (as able-bodied like 2C-I and 2C-C) were characterized by almost low levels of activity grant that compared to added phenethyalmines such at the same time that methylone and MBDB. However, this is not to send that the drugs acquire no monoamine acquittal backdrop – rather, reuptake is their unconditioned approach of action.
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