Natural reparative capacity of teeth elucidated




This advice release is available in French.

Researchers at Inserm and Paris Descartes University be favored with just taken an important step in research on stem cells and dental repair. They obtain managed to isolate dental stem lonely dwelling lines and to describe the normal mechanism by which they repair lesions in the teeth. This essential part discovery will make it possible to indoctrinate unprecedented therapeutic strategies to mobilise the sojourner dental stem cells and magnify their normal capacity for repair.

These results are published in the daily register Stem Cells.

The tooth is a mineralised instrument, implanted in the mouth by a radical. The “living” part of the tooth or dental cavity is the dental pulp (in golden in the photograph shown opposite) tranquil of vessels and nerves. Around it is a harsh substance, the dentine or ivory, that is in turn covered by an even harder tissue, the enamel. When a dental hurt appears, the dormant stem cells in the pulp awaken and try to repair the tooth by an unknown process.In this study, the researchers from Inserm and Paris Descartes University at Unit 1124, “Toxicology, Pharmacology and Cellular Signaling,” be seized of succeeded in extracting and isolating tooth trunk cells by working on the pulp from the mouse molar.

The researchers were in this wise able to analyse the cells in recount, and identify 5 specific receptors instead of dopamine and serotonin on their outside, two neurotransmitters that are essential to the dead ~ (see schema on page 2).

The state-room of these receptors on the external part of these stem cells indicated that they had the force to respond to the presence of dopamine and serotonin in the end of a lesion. The researchers naturally wondered the sort of cells might be the source of these neurotransmitters, a omen signal. It turns out that the noble extraction platelets, activated by the dental lesion, are responsible for releasing a liberal quantity of serotonin and dopamine. Once released, these neurotransmitters afterward recruit the stem cells to repair the tooth ~ dint of. binding to their receptors (see form on page 2). The research team was clever to confirm this result by observing that dental repair was abstracted in rats with modified platelets that cheat not produce serotonin or dopamine, i.e. in the abstraction of the signal.

“In stock cell research, it is unusual to exist simultaneously able to isolate cell lines, become identical the markers that allow them to have existence recognised (here the 5 receptors), reveal the signal that recruits them (serotonin and dopamine), and communicate the source of that signal (life-current platelets). In this work, we be in actual possession of been able, unexpectedly, to explore the unalloyed mechanism,” explains Odile Kellermann, cock of the walk of the team from Inserm and Paris Descartes University, and the the greater part author of this work.

To take things a boards further, the researchers tried to characterise the contrary receptors they found. One of the 5 receptors does not have the appearance to affect the repair process. On the other transmit, the other 4 turn out to have existence strongly involved in the repair course. In vivo blocking of just individual of them is enough to interrupt dental repair.

“Currently, dentists employment pulp capping materials (calcium hydroxide) and tricalcium phosphate-based biomaterials to repair the tooth and fill a glass lesions. Our results lead us to imagine unprecedented therapeutic strategies aimed at mobilising the inhabiting pulpal stem cells in order to exaggerate the natural reparative capacity of teeth destitute of use of replacement materials,” concludes Odile Kellermann.

The foundations be under the necessity been laid for extending this exploration done in rodents to stem cells of the human tooth in command to initiate new strategies for repairing teeth.



Essential roles of dopamine and serotonin in tooth repair: functional interplay between odontogenic stem cells and platelets

Anne Baudry1,2*, Aurélie Alleaume-Butaux1,2*, Sasha Dimitrova-Nakov1,2*, Michel

Goldberg1,2, Benoît Schneider1,2, Jean-Marie Launay3,4,5** & Odile Kellermann1,2**

1 INSERM UMR-S 1124, Cellules souches, Signalisation et Prions, 75006 Paris, France.

2 Université Paris Descartes, Sorbonne Paris Cité, UMR-S 1124, 75006 Paris, France.

3 AP-HP, Service de Biochimie, Hôpital Lariboisière, 75010 Paris, France

4 INSERM U942, Hôpital Lariboisière, 75010 Paris, France

5 Pharma Research Department, F. Hoffmann-La-Roche Ltd., CH-4070 Basel, Switzerland

Stem Cells, 7 avril 2015

Doi: 10.1002/forepart .2037

Investigator contact

Odile Kellermann
Inserm Unit 1124, “Toxicology, Pharmacology and Cellular Signaling” (Inserm/Paris Descartes University)
Leader of Inserm Team “Stem Cells, Signaling and Prions”
01 42 86 20 65

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