Making Tumors Glow
One of the greatest challenges facing a cancer surgeon for the time of an operation is determining where the tumor begins and ends. The surgeon of necessity to remove as much malignant tissue as possible, leaving few or none cancer cells that might cause the infirmity to recur.
Currently, that means sending samples to the pathology lab for the time of an operation for analysis, cutting off until the lab reports a according, cancer-free margin around the excised tumor. But cancer cells are small. They hide. They can be overlooked. Wouldn’t it have ~ing great if cancer cells announced their neighborhood, pretty much directing the surgeon to what to operate?
Work by Quyen T. Nguyen, MD, PhD, professor of Head and Neck Surgery at UC San Diego School of Medicine, in collaboration by Nobel laureate Roger Tsien, PhD, professor of pharmacology, is pushing that contingency closer to reality.
Nguyen, Tsien and colleagues bear developed fluorescent molecules that attach to targeted cancer cells and actually glow, identifying tissues that need to subsist removed. The same approach is moreover being used with molecules that highlight knotty-to-see nerves, helping surgeons fight shy of damaging them.
So far, the labor has been limited to successful dumb creature models, but researchers anticipate human trials later this year. Watch a modern video about the research, produced through the National Institute of Biomedical Imaging and Bioengineering.
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