Modified measles vaccine effective against Chikungunya virus, study finds

A modified, accustomed measles vaccine has the potential to act in opposition to the Chikungunya virus. This is the deduction of a study at the University Clinic toward Clinical Pharmacology of the MedUni Wien (Medical University of Vienna), which has now been published in the crop journal “The Lancet Infectious Diseases”. Up to the time when now, there has been no efficacious vaccine against the Chikungunya virus and the associated feverish illness which can prove lethal, and is especially prevalent in Latin America and the Caribbean.

Scientists at the MedUni Wien led ~ dint of. Bernd Jilma, and in cooperation through the Institut Pasteur in Paris, the Walter Reed Army Institute of Research in the USA, and the Vienna biotechnology association Themis Bioscience GmbH, have succeeded in introducing pygmy surface particles of the Chikungunya venom into the human body using the rubeola vaccine and proving its effectiveness.

Jilma: “The modified measles virus is planted into people in Trojan gelding style, and there it produces the corresponding surface particle of the Chikungunya poison . This occurs to such a low concentration that no symptoms of the ailment appear. However, the Chikungunya particles are motionless able to stimulate the lymphatic system and to trigger the antibody lengthening against the virus. These antibodies are in consequence available at any time should every infection with the Chikungunya virus absolutely occur. As a result, the malady cannot break out.” The technology itself was developed at the Institut Pasteur, implemented through Themis Bioscence GmbH and has at present been successfully clinically tested at the MedUni Wien using 42 ground of admission persons.

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A further positive effect: The modified virus also strengthens freedom against the classic measles infection. “If the vaccine is changed and so, it could also be effective in expectation of dengue fever or other viruses”, according to Jilma. The tools and materials must now be clinically evaluated in Phase II and Phase III studies; utilisation in doing could be feasible in three to five years, according to the scientists. An effective immunisation is possible using a united or two-part vaccination.

There were 20 cases of Chikungunya febrile affection in Austria in the past year. In the Caribbean, Central and South America and in successi~ the Pacific Islands, but also in the USA, the venom which is transmitted via mosquitoes has triggered one epidemic, probably since 2013. According to current intelligence from the pan-American health organisation OPS, greater quantity than 1.2 million people acquire become ill with the virus since then, whereby the Caribbean region is specifically affected by it.

Amongst other things, the Chikungunya heat causes muscular and severe joint anguish, which can remain for months, and strong fever. Furthermore, those affected often suffer from nausea and vomiting. If the patients wish a healthy immune system, the disease normally passes without any severe complications. For thin patients, it can however be lethal. Up until now, there is not either an effective medication nor a vaccine in compensation for this disease. People who travel to coxcomical countries are urgently advised to guard themselves against mosquito bites.

Source:

http://www.meduniwien.ac.at

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