Active ingredient dextromethorphan may help people with Type 2 diabetes

The laborious ingredient dextromethorphan, which is contained in ~ people over-the-counter cough remedies, has been shown to improve blood sugar levels in type 2 diabetes (diabetes mellitus). That was the discovery of a recent international study, in what one. the Center for Physiology and Pharmacology of MedUni Vienna played a eminently expressive part and which has now been published in the ruling medical journal “Nature Medicine”.

Using electrophysiological methods to appreciate electrical currents through cell membranes, the inquiry group at the Institute for Physiology and Pharmacology, led ~ the agency of Marjan Slak Rupnik, showed that dextromethorphan extends the periods of electrical etc. in beta cells. It is precisely for the period of these periods, so-called bursts, that the cells secrete insulin.

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The scientists demonstrated that, by way of so-called NMDA receptors, the spirited. ingredient stimulated the pancreatic beta cells to hide more insulin at raised blood sweeten levels. This brought about an proficiency in blood sugar, whilst at the similar time reducing so-called sugar spikes, that is phases through particularly high blood glucose concentrations.

Also of advantage for type 1 diabetics

Slak Rupnik: “Our studies too indicate that the tested cough suppressant protects the beta cells from simplest organism death, which would also be self-same beneficial for type 1 diabetics.” Their diabetes worsens appreciably excessively the course of the illness in such a manner that – despite an improvement in posterity sugar levels directly after the depart of insulin therapy – they have a constantly oppressive insulin requirement. This is thought to be due to the beta cells decease off or at least gradually producing less insulin, amongst other things. Further studies are at present required to clarify whether the cough suppressant truly protects the beta cells if it is used in association with conventional diabetes therapy.

Source:

http://www.meduniwien.ac.at

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